The Best NR Supplements

Nicotinamide Riboside (NR) Supplements

Nicotinamide Riboside (NR) supplements have become increasingly popular in recent years, touted as a potential cellular fountain of youth. Let’s explore the top NR supplements available and how they might benefit your health and longevity.

Understanding NR and NAD+

To fully appreciate the potential of NR supplements, it’s crucial to understand the basics of NR and its role in our bodies. Nicotinamide Riboside is a form of vitamin B3 that acts as a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in all living cells.

NAD+ plays a vital role in many cellular processes, including:

1. Energy production
2. DNA repair
3. Gene expression
4. Cellular communication
5. Regulation of circadian rhythms

As we age, our natural levels of NAD+ decline, which is believed to contribute to various age-related health issues. This is where NR supplements come into play – they aim to boost NAD+ levels, potentially slowing down the aging process and improving overall cellular health.

The Science Behind NR Supplements

Research on NR supplements is still in its early stages, but the results so far are promising. Several studies have demonstrated that NR supplementation can effectively increase NAD+ levels in humans.

Some potential benefits observed in clinical trials include:

1. Improved mitochondrial function
2. Enhanced cognitive performance
3. Better sleep quality
4. Increased exercise endurance
5. Improved cardiovascular health

While more research is needed to fully understand the long-term effects of NR supplementation, many scientists and health enthusiasts are excited about its potential.

Top NR Supplements on the Market

Now that we’ve covered the basics, let’s explore some of the best NR supplements available:

1. Tru Niagen Pro NAD+

Tru Niagen is widely regarded as one of the most well-known and extensively researched NR supplements on the market. Developed by ChromaDex, this supplement contains a patented form of NR called NIAGEN®.

Pros:

• Backed by many clinical studies
• Available in various dosages (300mg, 500mg, 900mg)
• Third-party tested for purity and potency
• NSF Certified for Sport®

Cons:

• Higher price point compared to some competitors
• Some users report mild digestive discomfort

Tru Niagen has set the standard for NR supplements with its research-backed formula and high-quality manufacturing processes. The company offers flexible dosing options, allowing users to find the right amount for their needs.

Check Out Tru Niagen Pro NAD+ on Amazon

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Read full Tru Niagen Pro NAD+ review.

2. Elysium Basis NAD Plus

Elysium Basis takes a unique approach by combining NR with pterostilbene, a polyphenol found in blueberries that may offer extra anti-aging benefits.

Pros:

• Combination of NR and pterostilbene for potential synergistic effects
• Subscription model available for cost savings
• Backed by a scientific advisory board of renowned researchers

Cons:

• Limited third-party testing information available
• Some users find the subscription model inconvenient

Elysium’s focus on scientific research and its innovative formulation make it an intriguing option for those looking to maximize the potential benefits of NR supplementation.

Check out Elysium Basis NAD Plus on Amazon

3. Life Extension NAD+ Cell Regenerator and Resveratrol Elite

Life Extension’s NAD+ Cell Regenerator and Resveratrol Elite combines NIAGEN nicotinamide riboside with trans-resveratrol, aiming to support cellular energy and combat oxidative stress. ​

Pros:

• Contains well-researched ingredients like nicotinamide riboside and trans-resveratrol.​
• Some users report increased energy levels and improved focus.

Cons:

• Premium pricing compared to other NAD+ supplements.​
• Some users experience gastrointestinal discomfort. ​

Life Extension’s NAD+ Cell Regenerator and Resveratrol Elite offers a blend of ingredients aimed at promoting cellular health, though individual experiences may vary.

Check out Life Extension NAD+ Cell Regenerator and Resveratrol Elite on Amazon

4. Thorne ResveraCel

Thorne ResveraCel combines NR with resveratrol, quercetin, and betaine, creating a comprehensive anti-aging formula designed to support cellular energy production and overall health.

Pros:

• Unique blend of ingredients for potential synergistic effects
• NSF Certified for Sport®
• Reputable brand with high-quality standards

Cons:

• Higher price point because of extra ingredients
• Complex formula may not be suitable for those seeking pure NR

Thorne’s ResveraCel offers a more holistic approach to NAD+ boosting and anti-aging support, making it an attractive option for those looking for a multi-faceted supplement.

Check out Thorne ResveraCel on Amazon

5. Genex Formulas Nicotinamide Riboside

HPN Supplements offers a straightforward NR supplement using the patented NIAGEN® form. This Genex Formulas offers a Nicotinamide Riboside (NR) supplement designed to support healthy aging and boost NAD+ levels. ​

Pros:

• Provides 300 mg of Nicotinamide Riboside per serving.​
• Non-GMO, gluten-free, and vegetarian-friendly.​
• Manufactured in a GMP-certified facility, ensuring quality and safety standards.​

Cons:

• Some users may prefer a higher dosage per serving.​
• Limited brand recognition compared to more established competitors.​

Genex Formulas’ Nicotinamide Riboside supplement offers a straightforward approach to enhancing NAD+ levels, catering to those seeking a simple and clean formulation.​

Check out Genex Formulas Nicotinamide Riboside on Amazon

Factors to Consider When Choosing an NR Supplement

When selecting an NR supplement, keep the following factors in mind:

Purity and Quality

Look for supplements that use patented forms of NR, such as NIAGEN®, and undergo third-party testing for purity and potency. This confirms that you’re getting a high-quality product that contains the advertised amount of NR.

Dosage

Consider the amount of NR per serving and how it aligns with the dosages used in clinical studies (typically 250-1000mg per day). Some people may prefer starting with a lower dose and gradually increasing it, while others may opt for a higher dose based on their health goals.

Additional Ingredients

Some supplements mix NR with other compounds that may offer synergistic benefits. Decide whether you prefer a pure NR supplement or a more comprehensive formula that includes other potentially beneficial ingredients like resveratrol or pterostilbene.

Brand Reputation

Choose supplements from reputable brands with a history of quality and transparency. Look for companies that invest in research and have a strong track record in the supplement industry.

Price

Compare the cost per serving across different brands, keeping in mind that higher prices don’t always equate to better quality. Consider your budget and the value you’re getting for your money.

Personal Sensitivities

Be aware of any allergies or sensitivities you may have to specific ingredients or fillers used in the supplements. Always check the full list of ingredients before purchasing.

How to Incorporate NR Supplements into Your Routine

When starting with NR supplementation, it’s best to begin with the recommended dosage on the product label. Here are some tips for incorporating NR supplements into your routine:

1. Take the supplement at the same time each day to establish a consistent routine.
2. Some people prefer taking NR in the morning for an energy boost, while others find it beneficial before bed.
3. If you experience any digestive discomfort, try taking the supplement with food.
4. Be patient – it may take several weeks to notice any significant effects.
5. Consider cycling your NR supplementation (e.g., taking breaks every few months) to prevent tolerance buildup.

Potential Side Effects and Precautions

While NR supplements are generally considered safe, some users may experience mild side effects such as:

• Nausea or stomach discomfort
• Headaches
• Fatigue
• Mild flushing

If you experience any persistent or severe side effects, stop use and ask with a healthcare professional.

It’s also important to note that NR supplements may interact with certain medications or medical conditions. Always ask with your doctor before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

The Future of NR Research

As interest in NR supplementation continues to grow, we can expect to see more research exploring its potential benefits and long-term effects. Some areas of ongoing investigation include:

1. NR’s role in neurodegenerative diseases like Alzheimer’s and Parkinson’s
2. The potential of NR in cancer prevention and treatment
3. NR’s effects on metabolic health and insulin sensitivity
4. The impact of NR on muscle strength and recovery in aging populations

As more studies are conducted, we’ll gain a clearer understanding of how NR supplementation can be optimized for various health goals and age groups.

Combining NR Supplements with a Healthy Lifestyle

While NR supplements show promise in supporting cellular health and combating the effects of aging, it’s important to remember that they are not a magic bullet. To maximize the potential benefits of NR supplementation, consider incorporating the following lifestyle habits:

Balanced Diet

Consume a diet rich in whole foods, including plenty of fruits, vegetables, lean proteins, and healthy fats. These foods provide essential nutrients that work synergistically with NR to support overall health.

Regular Exercise

Engage in a combination of cardiovascular exercise and strength training. Physical activity has been shown to naturally boost NAD+ levels and improve overall cellular health.

Quality Sleep

Prioritize getting 7-9 hours of quality sleep each night. Good sleep habits are crucial for maintaining healthy NAD+ levels and supporting overall cellular function.

Stress Management

Practice stress-reduction techniques such as meditation, yoga, or deep breathing exercises. Chronic stress can reduce NAD+ levels and accelerate cellular aging.

Limit Alcohol and Tobacco Use

Excessive alcohol consumption and tobacco use can reduce NAD+ levels and contribute to cellular damage. Reducing or eliminating these habits can support the effectiveness of NR supplementation.

NR Supplements and Specific Health Concerns

While research is ongoing, NR supplements have shown potential benefits for various health concerns. Here’s a closer look at how NR might help with specific issues:

Cognitive Function

Some studies suggest that NR supplementation may improve cognitive function, particularly in older adults. By supporting mitochondrial health and DNA repair, NR could potentially help maintain brain health and reduce the risk of age-related cognitive decline.

Cardiovascular Health

NR has shown promise in supporting cardiovascular health by improving blood pressure regulation and arterial function. Some research indicates that NR supplementation may help reduce the risk of heart disease and improve overall cardiovascular function.

Metabolic Health

NR may play a role in improving metabolic health by enhancing insulin sensitivity and glucose metabolism. This could be particularly beneficial for people at risk of or managing type 2 diabetes.

Athletic Performance

Some athletes and fitness enthusiasts use NR supplements to potentially enhance exercise performance and recovery. While more research is needed, preliminary studies suggest that NR may improve muscle function and endurance.

Skin Health

NAD+ plays a role in DNA repair, which is crucial for maintaining healthy skin. Some early research suggests that NR supplementation may help improve skin appearance and reduce signs of aging.

NR Supplements vs. Other NAD+ Boosters

While NR is a popular choice for boosting NAD+ levels, it’s not the only option available. Here’s how NR compares to other NAD+ precursors:

Nicotinamide Mononucleotide (NMN)

NMN is another precursor to NAD+ that has gained attention in recent years. While both NR and NMN can effectively boost NAD+ levels, NR has been more extensively studied in humans and may have better bioavailability.

Niacin (Nicotinic Acid)

Niacin is a form of vitamin B3 that can also increase NAD+ levels. However, it often causes uncomfortable flushing and may have more side effects compared to NR.

Nicotinamide (NAM)

Nicotinamide is another form of vitamin B3 that can boost NAD+ levels. While it’s generally well-tolerated, it may not be as effective as NR in raising NAD+ levels in certain tissues.

Dosage Considerations for NR Supplements

The optimal dosage of NR can vary depending on individual factors and health goals. Here are some general guidelines:

• Most clinical studies have used doses ranging from 250mg to 1000mg per day.
• Many people start with a lower dose (e.g., 250mg) and gradually increase if needed.
• Some people may benefit from higher doses, but it’s important to ask with a healthcare professional before exceeding the recommended dosage on the product label.
• Splitting the daily dose into two servings (morning and evening) may help maintain more consistent NAD+ levels throughout the day.

Potential Drug Interactions with NR Supplements

While NR is generally considered safe, it’s important to be aware of potential interactions with certain medications:

• Blood thinners: NR may affect blood clotting, so people taking anticoagulants should ask their doctor before using NR supplements.
• Diabetes medications: NR may impact blood sugar levels, potentially affecting the dosage requirements for diabetes medications.
• Statins: Some research suggests that NR may enhance the effects of statins, potentially allowing for lower doses of these cholesterol-lowering drugs.

Always tell your healthcare provider about any supplements you’re taking, including NR, to ensure there are no contraindications with your current medications or health conditions.

The Role of NAD+ in Cellular Health

To fully appreciate the potential benefits of NR supplements, it’s helpful to understand the crucial role that NAD+ plays in cellular health:

Energy Production

NAD+ is essential for the process of cellular respiration, which converts nutrients into energy that cells can use. By boosting NAD+ levels, NR supplements may help improve overall energy production and metabolism.

DNA Repair

NAD+ is a critical component in the DNA repair process. As we age, our ability to repair DNA damage decreases, which can contribute to various age-related health issues.

NR supplementation may help support the body’s natural DNA repair mechanisms.

Sirtuins Activation

NAD+ activates a group of proteins called sirtuins, which play a crucial role in regulating cellular health, longevity, and stress resistance. By increasing NAD+ levels, NR supplements may help enhance sirtuin activity and potentially slow down aspects of the aging process.

Circadian Rhythm Regulation

NAD+ levels naturally fluctuate throughout the day, playing a role in regulating our circadian rhythms. NR supplementation may help support healthy sleep-wake cycles and improve overall sleep quality.

NR Supplements and Longevity Research

The potential anti-aging effects of NR have made it a subject of interest in longevity research. While human studies are still in their early stages, animal research has shown promising results:

• Increased lifespan in some animal models
• Improved healthspan (the period of life spent in good health)
• Enhanced cellular resilience to various stressors

As research progresses, we may gain more insights into how NR supplementation could potentially impact human longevity and healthy aging.

Choosing the Right NR Supplement for You

With the variety of NR supplements available, choosing the right one can feel overwhelming. Here are some extra factors to consider:

Form of NR

Look for supplements that use a patented, stabilized form of NR, such as NIAGEN®. These forms have been specifically developed for optimal absorption and efficacy.

Delivery Method

NR supplements come in various forms, including capsules, tablets, and powders. Choose the form that best fits your preferences and lifestyle.

Certifications

Look for supplements that have third-party certifications for quality and purity, such as NSF or USP verification.

Customer Reviews

While individual experiences can vary, reading customer reviews can provide insights into the effectiveness and potential side effects of different NR supplements.

Company Transparency

Choose brands that are transparent about their sourcing, manufacturing processes, and quality control measures.

The Importance of Consistency with NR Supplementation

To experience the potential benefits of NR supplements, consistency is key. Here’s why:

• NAD+ levels can fluctuate quickly, so regular supplementation helps maintain optimal levels.
• Some benefits of NR supplementation may take weeks or even months to become noticeable.
• Consistent use allows you to better assess the supplement’s effects on your health and well-being.

Consider setting reminders or incorporating NR supplementation into your daily routine to ensure consistent use.

Monitoring the Effects of NR Supplementation

While the effects of NR supplementation can be subtle, there are several ways to watch its potential impact on your health:

• Keep a journal to track changes in energy levels, sleep quality, and cognitive function.
• Consider regular check-ups with your healthcare provider to watch relevant biomarkers.
• Pay attention to changes in exercise performance and recovery.
• Note any improvements in skin appearance or overall well-being.

Remember that individual responses to NR supplementation can vary, and it may take time to notice significant changes.

The Future of NR Research and Development

As interest in NR and NAD+ boosting continues to grow, we can expect to see exciting developments in the field:

• More human clinical trials to further establish the benefits and optimal dosages of NR supplementation
• Development of new delivery methods for improved absorption and efficacy
• Research into combining NR with other compounds for enhanced benefits
• Exploration of NR’s potential in treating specific health conditions

Staying informed about the latest research can help you make educated decisions about NR supplementation and its role in your health regimen.

People Also Asked

What is the best time of day to take NR supplements?

The optimal time to take NR supplements can vary depending on individual preferences and responses. Some people prefer taking them in the morning for an energy boost, while others find them beneficial before bed. Experiment to find what works best for you.

How long does it take to see results from NR supplementation?

The time frame for noticing effects from NR supplementation can vary. Some people report feeling benefits within a few weeks, while for others, it may take several months of consistent use.

Can NR supplements help with fat loss?

While NR supplements are not primarily designed for fat loss, some research suggests they may support metabolic health and energy production, which could indirectly help with weight management efforts.

Are there any foods that naturally contain NR?

NR is not commonly found in significant amounts in food sources. However, other NAD+ precursors like niacin (vitamin B3) can be found in foods such as meat, fish, nuts, and seeds.

Can NR supplements improve exercise performance?

Some studies suggest that NR supplementation may enhance exercise performance and recovery, particularly in older adults. However, more research is needed to fully understand its effects on athletic performance.

Is it safe to take NR supplements long-term?

Current research suggests that NR supplements are safe for long-term use at recommended doses. However, as with any supplement, it’s important to ask with a healthcare professional before starting a long-term regimen.

Can NR supplements help with jet lag?

Given NAD+’s role in regulating circadian rhythms, some people use NR supplements to help manage jet lag. While anecdotal evidence is promising, more research is needed to confirm its effectiveness for this purpose.

Do NR supplements interact with other vitamins or minerals?

NR supplements generally don’t have significant interactions with other vitamins or minerals. However, it’s always best to ask with a healthcare professional before combining multiple supplements.

Can NR supplements help with menopausal symptoms?

Some preliminary research suggests that NR supplementation may help reduce certain menopausal symptoms, particularly those related to energy levels and sleep quality. However, more studies are needed in this area.

Are there any age restrictions for taking NR supplements?

Most NR supplements are marketed towards adults. While they are generally considered safe, it’s best to ask with a pediatrician before giving NR supplements to children or adolescents.

Key Takeaways

• NR supplements aim to boost NAD+ levels, potentially supporting cellular health and longevity.
• Top NR supplements include Tru Niagen, Elysium Basis, Life Extension NAD+ Cell Regenerator, Thorne ResveraCel, and HPN Supplements N(R) Niagen.
• When choosing an NR supplement, consider factors such as purity, dosage, extra ingredients, and brand reputation.
• While generally safe, be aware of potential side effects and start with a lower dose to assess your body’s response.
• Combining NR supplementation with a healthy lifestyle may maximize its potential benefits.